منابع مشابه
Spindle assembly at a BRISC pace
Yan et al. describe how a deubiquitinating enzyme complex regulates the mitotic spindle assembly factor NuMA. BRCC36 is a de-ubiquitinating enzyme that preferentially cleaves lysine 63–linked poly-ubiquitin chains. As part of the Rap80 complex, BRCC36 regulates the repair of DNA double-strand breaks, but the enzyme can also assemble into a distinct complex, known as BRISC. Yan et al. found that...
متن کاملThe deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and play an important role in diverse physiological processes, including mitotic division. The BRCC36 isopeptidase complex (BRISC) is a DUB that is specific for lysine 63-linked ubiquitin hydrolysis; however, its biological function remains largely undefined. Here, we identify a critical role for BRISC in the control of ...
متن کاملMetaphase Spindle Assembly
A microtubule-based bipolar spindle is required for error-free chromosome segregation during cell division. In this review I discuss the molecular mechanisms required for the assembly of this dynamic micrometer-scale structure in animal cells.
متن کاملThe Spindle Assembly Checkpoint
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint ...
متن کاملThe spindle assembly checkpoint
Italian in 1954, so Imanishi turned to the exploration of the unexplored wide range of Karakorum Himalayas, traversing the three major glaciers in 1955. Then, in 1958, Imanishi and Itani went to Africa for the first time. In the same year, Nishibori led the all-Japanese team which succeeded in the first over-wintering stay in Antarctica. Kuwabara led the Himalayan expedition of AACK to the firs...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2102iti1